Linzess vs Rezdiffra
A side-by-side look at two gastrointestinal medications advertised on TV. Informational only — not medical advice.
Maintained by TVPills Editorial Team · Site updated November 4, 2026 (not a product-label review)
| Attribute | US Linzess | US Rezdiffra |
|---|---|---|
| Generic name | linaclotide Unverified catalogue summary (Generic name) for Linzess in US; not checked against current local product information. | resmetirom Unverified catalogue summary (Generic name) for Rezdiffra in US; not checked against current local product information. |
| Drug class | See official local label Unverified catalogue summary (Drug class) for Linzess in US; not checked against current local product information. | See official local label Unverified catalogue summary (Drug class) for Rezdiffra in US; not checked against current local product information. |
| Treats | IBS with constipation (age 7+), adult chronic idiopathic constipation, pediatric functional constipation (age 2+) Unverified catalogue summary (Treats) for Linzess in US; not checked against current local product information. | Metabolic dysfunction-associated steatohepatitis (MASH) Unverified catalogue summary (Treats) for Rezdiffra in US; not checked against current local product information. |
| Category | Gastrointestinal Unverified catalogue summary (Category) for Linzess in US; not checked against current local product information. | Gastrointestinal Unverified catalogue summary (Category) for Rezdiffra in US; not checked against current local product information. |
| Manufacturer | AbbVie Inc./Ironwood Pharmaceuticals, Inc. (US marketers) Unverified catalogue summary (Manufacturer) for Linzess in US; not checked against current local product information. | Madrigal Pharmaceuticals Unverified catalogue summary (Manufacturer) for Rezdiffra in US; not checked against current local product information. |
| Year approved | — Unverified catalogue summary (Year approved) for Linzess in US; not checked against current local product information. | — Unverified catalogue summary (Year approved) for Rezdiffra in US; not checked against current local product information. |
| Catalogue warning level | Safety summary withheld — check official label Unverified catalogue summary (Catalogue warning level) for Linzess in US; not checked against current local product information. | Safety summary withheld — check official label Unverified catalogue summary (Catalogue warning level) for Rezdiffra in US; not checked against current local product information. |
| Est. TV ad spend | $140M | — |
| Side effects and serious risks | — Unverified catalogue summary (Side effects and serious risks) for Linzess in US; not checked against current local product information. | — Unverified catalogue summary (Side effects and serious risks) for Rezdiffra in US; not checked against current local product information. |
Rezdiffra
Sources and editorial standards
Use the current DailyMed labels to verify approved uses, boxed warnings, and side effects for each medication. Label results can differ by product, strength, and formulation.
Page updated November 4, 2026; the linked resources have not necessarily been reviewed on this date.
Frequently asked questions
Is Linzess or Rezdiffra better?
This directory does not compare clinical effectiveness or safety. Listing Linzess and Rezdiffra together does not establish shared approved indications, equivalence or suitability as substitutes. Consult the correct local labels and your prescriber.
What's the difference between Linzess and Rezdiffra?
The table shows catalogue identification and estimated advertising information for Linzess and Rezdiffra, not a verified medical comparison. Medical descriptions, mechanisms and safety summaries are withheld.
Which one spends more on TV ads?
Linzess has the larger estimated TV advertising budget of the two.